Megamind is a Mastermind.
- He can launch a sonic attack in the form of crescents.
- He can also summon two at a time of Medics and Witch Doctors from Pirate World, and Shamans from Medieval World, in the form of Abducted Medics, Abducted Doctors and Abducted Shamans, respectively.
- He has a modest force field.
Defeat Megamind for 25 points each as:
- (9) Plumber
- (10) Librarian
- (11) Grandma, Evil Mech,
- (12) Pizza Delivery Man, Space Miner
- (13) Alien Trooper, Disco Diva
- (14) Zombie Businessman
- Don't waste time breaking his summoned allies first, as he can summon some more.
- You may want to break his other allies first.